Koch postulate – Introduction, procedure,exception, classified disease, symptoms and limitations full overview

Koch postulate :-

  • Koch postulate was define in 1876 german scientist Robert Koch. Scientist Koch cultivate to bacillus anthrax using of blood serum.

Introduction of Koch postulate :-

  • The disease may be  present in every died animal but absent in healthy individuals.
  • The agent of Koch postulate is must be isolated and cultured in-vitro.
  • Culture of this disease is cultivated in laboratory condition.
  • Robert Koch discovered different disease and microorganisms such as tuberculosis mycobacterium, Vibrio cholera and Bacillus  anthracis.
  • Robert Koch play  important role in microbiology and also known as father of bacteriology.

Procedure of Koch postulate :-

Koch postulates
Koch postulates
  • Microorganisms are isolated from dead animals.
  • Then organisms are grown in pure culture medium.
  • After growing of organisms then organisms are identified.
  • Later microorganisms are injected into the  healthy animals.
  • Then disease is produced in second animal.
  • After we again grow microorganism on the pure culture medium.
  • Then identification of microorganisms in culture medium.

Exception of Koch postulate :-

  • Microorganisms that are not able to culture on artificial media E.g. Treponema pallidum.
  • When two or more organisms are work together then they cause infection.
  • Symptoms and diseases can be caused by any one of different organism.
  • Not all the disease behave the same.
  • Disease very widely in their duration, onset and level of activity.

Classified disease :-

  1. Acute disease :- Symptoms develop rapidly and tend to be more severe.
  2. Chronic disease :- Symptoms develop slowely and are less severe.
  3. Sub-acute disease :- Symptoms of both acute and chronic are present.
  4. Latent disease :- Disease with a period of no symptoms when the causative agent in active.

Symptoms in plants and humans :-

  • Yellowing of leaves and spots on plant parts.
  • Rotted plant parts and dead tissue.
  • In human fever, headache and loose motion like symptoms are appear.

Limitation of Koch postulate :-

  • Some microorganisms are cannot grow on the pure culture medium.
  • Using humans in completing the postulates is unethical.
  • Molecular and genetic evidence can be replace in postulate.
  • Disease production can need co-factor.
  • Always not possible to isolate organisms from disease person.
  • Virus cannot be cultured like bacteria because living cell to grow.
  • Always infection does not produce infection.
  • Pathogen can be present without clinical disease.

Add a Comment

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.